Farm Exquisite Blood fast in Diablo 4 via Helltides, Nightmare Dungeons, and Legion Events, then spend 12 vials to summon Lord Zir for top-tier uniques and build-changing loot.
If you've put serious hours into Diablo 4, you've probably hit that moment where your build feels "almost there" and then stalls out hard. It's usually one Unique away from clicking, and Lord Zir is the obvious target, but the real choke point is Exquisite Blood. If you're short, your whole night turns into running errands instead of getting drops. Some folks even top up missing mats through trading or services like EZNPC when they'd rather spend their limited playtime actually fighting bosses than chasing one more vial.
Helltide Loop That Actually Pays
When Helltide's live, treat it like your main job. Don't just roam. Head toward where you can keep pressure on elites and events, because you need Cinders fast. Your first goal is Baneful Hearts from Tortured Gift chests, then you pivot straight into the Blood Maiden loop. Summon her, burn her down, scoop the guaranteed Exquisite Blood, then clear the nearby packs while you're already in the mess. You'll notice the area refills quickly, so you're not wasting time riding across the zone. If you're solo, it still works, but if randoms show up, let them. More bodies means more summons, more kills, and less downtime.
When Helltide's Off, Keep It Moving
Helltide isn't always up, and staring at the map doesn't farm anything. Nightmare Dungeons are the steady fallback, even if the Blood drops feel moody. The trick is pace. Skip the sightseeing. Kill elites, smash objectives, and get to the boss. If a run drags, you're leaking efficiency, so tune your tier to whatever you can clear cleanly without sweating every pull. Legion Events are solid in-between content too. They're quick, they're social, and the chest pop at the end is basically a cheap lottery ticket for Blood while you're stacking other mats.
Turning Vials Into Real Attempts
Once you've got enough for a session, head to the Ancient's Seat in Fractured Peaks and start thinking like you're spending a currency, because you are. Zir costs 12 Exquisite Blood per summon, so don't blow it on sloppy runs. Do 1 thing first: find a rotation group. You pay your 12 when it's your turn, but you still get loot from everyone else's summons, which is the whole point. Pop a potion, bring incense if you've got it, and aim for quick, repeatable kills. The faster the cycle, the more chances you get, and if you're still missing that key piece, checking a trusted marketplace for Diablo 4 iteams can be a practical way to keep your build moving while the RNG catches up.